Clinical Trials

Electrophysiology
WATCHMAN FLX™ Pro Left Atrial Appendage Closure Device With Alternative Post-Implant Monotherapy

Electrophysiology
Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices

Heart Failure
Assessment of Implantable CCM in the Heart FaIlure Group with Higher Ejection Fraction (AIM HIGHer)

Heart Failure 
A Prospective, Multi-Center, Open Label, Randomized Control Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in New York Heart Association (NYHA) Class II -III Heart Failure Patients (PROACTIVE- HF-2 Trial)

Heart Failure 
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients (REDEFINE-HF)

Heart Failure 
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients with Heart Failure (CONFIRMATION-HF)

Heart Failure 
A randomized, double-blind, placebo-controlled pragmatic study to evaluate FINerenone on clinicAL effIcacy and safeTY in patients with Heart Failure and reduced ejection fraction who are intolerant of or not eligible for treatment with steroidal mineralocorticoid receptor antagonists

Heart Failure 
Randomized trial of ELEVATEd cardiac pacing rate for personalized treatment of Heart Failure with preserved Ejection Fraction (ELEVATEHFpEF)

Heart Failure 
A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Assess Efficacy and Safety of an oral HF therapy in Patients with Symptomatic Heart Failure with Severely Reduced Ejection Fraction

Heart Failure 
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients with Advancing Heart Failure

Heart Failure 
RELIVE Trial- Randomized Evaluation of Less Invasive Ventricular Enhancement

Hypertension

The Global Paradise® System US Post Approval Study

Hypertrophic Cardiomyopathy

An Open-Label Study of CK­3773274 for Patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)

Hypertrophic Cardiomyopathy
An Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EDG-7500 in Adults with Hypertrophic Cardiomyopathy

Left Atrial Appendage

The CONFORM Pivotal Trial -An Evaluation of the Safety and Effectiveness of the Conformal CLAAS System for Left Atrial Appendage Occlusion

Mitral Regurgitation

This is a prospective, single arm, multicenter, clinical trial designed to evaluate the safety and performance of the AltaValve System for the treatment of mitral regurgitation in a targeted patient population

Mitral Valve

Percutaneous or surgical Repair In Mitral prolapse And Regurgitation for ≥ 65 Year-olds

Percutaneous Coronary Intervention (PCI)

Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II (COSIRA-II)

Postural Orthostatic Tachycardia Syndrome (POTS)

A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in Patients with Postural Orthostatic Tachycardia Syndrome

Valvular Diseases

Explanted Heart Valve Registry

Women's Cardiovascular Health

Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy for Peripartum Cardiomyopathy (REBIRTH)

Women's Cardiovascular Health

Heart Outcomes in Pregnancy Expectations (HOPE) for Mom and Baby

Women's Cardiovascular Health
Pregnancy Complications Leading to Cardiovascular Disease Outcomes Registry

Women's Cardiovascular Health
Monitoring outcomes for multidisciplinary care of women with cardiac disease in pregnancy: Creating a Cardio-Obstetrics Outcomes Log (COOL)

Women's Cardiovascular Health
iSCAD Registry